Among the several methods currently available for protein purification, only one offers the benefits of a largely matrix-free system, allowing proteins to be purified in their native state. This is important because protein conformation and behavior can be altered due to interactions with membranes or beads, changing the true character of the protein you seek to characterize. Under matrix-free conditions, such as those found within high-performance centrifuges, it becomes possible not only to purify by molecular weight, but also by density and conformation, features unavailable with membrane-based purification techniques. A centrifuge can generate the exact forces needed to purify (and, when needed, quantitate) a protein sample for research or therapeutic use.

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